Predictive Value of Perilesional Fundus Autofluorescence Patterns and OCT-Based Ellipsoid Zone/Retinal Pigment Epithelium Loss Ratios in Geographic Atrophy Growth Rates.

Julia Mai^1,2, Gregor S Reiter^1,2, Sophie Riedl^1,2, Wolf-Dieter Vogl³, Amir Sadeghipour³, Alex McKeown⁴, Emma Foos⁴, Roy Schwartz^4,5, Stefan Sacu², Hrvoje Bogunovic⁶, Ursula Schmidt-Erfurth¹

¹OPTIMA - Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

²Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

³RetInSight, Vienna, Austria.

⁴Apellis Pharmaceuticals, Boston, Massachusetts.

⁵Moorfields Eye Hospital NHS Foundation Trust, London, UK.

⁶Institute of Artificial Intelligence/Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.

PubMed PMC DOI PDF

Abstract

PURPOSE: To investigate the association between perilesional fundus autofluorescence (FAF) patterns and ellipsoid zone (EZ)/retinal pigment epithelium (RPE) loss ratio on OCT in geographic atrophy (GA) and their predictive value on disease progression and therapeutic response to pegcetacoplan. DESIGN: Post hoc analysis of 2 prospective randomized controlled phase III clinical trials. SUBJECTS: P…

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