Lesion-Centered Functional Trajectories Reveal Early Retinal Sensitivity Decline in Intermediate Age-Related Macular Degeneration: PINNACLE Study Report 15.

Stefan Futterknecht¹, Sophie Riedl², Julia Mai², Sina Arabi², Ursula Hall¹, Hrvoje Bogunovic³, Lars G Fritsche⁴, Daniel Rueckert⁵, Martin J Menten⁶, Stefan Sacu², Ursula Schmidt-Erfurth², Sobha Sivaprasad⁷, Andrew Lotery⁸, Maximilian Pfau⁹

¹From the Institute of Molecular and Clinical Ophthalmology Basel (S.F. and U.H.), Basel, Switzerland; University Hospital Basel (S.F., U.H., M.P.), Basel, Switzerland.

²Medical University of Vienna (S.R., J.M., S.A., S.S., U.S.E.), Vienna, Austria.

³Institute for Artificial Intelligence (H.B.), Center for Medical Data Science, Medical University of Vienna, Vienna, Austria.

⁴University of Michigan (L.G.F.), Ann Arbor, Michigan, USA.

⁵TUM University Hospital and Technical University of Munich (D.R. and M.J.M.), Munich, Germany; Imperial College London (D.R.), London, UK.

⁶TUM University Hospital and Technical University of Munich (D.R. and M.J.M.), Munich, Germany.

⁷Moorfields Eye Hospital (S.S.), London, UK.

⁸University of Southampton (A.L.), Southampton, UK.

⁹University Hospital Basel (S.F., U.H., M.P.), Basel, Switzerland; University of Bonn (M.P.), Bonn, Germany. Electronic address: maximilian.pfau@ukbonn.de.

PubMed DOI

Abstract

PURPOSE: To characterize lesion-centered functional decline in intermediate age-related macular degeneration, including measurement variability, spatial vulnerability, predetection functional changes, and lesion-specific sensitivity trajectories. DESIGN: Longitudinal analysis of microperimetry from the prospective, multicenter PINNACLE study (NCT06682455). PARTICIPANTS: Overall, 264 participants…

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