p53 deficiency increases vulnerability to chronic stress-induced anxiety- and depression-like behaviors: Role of calcium dysregulation and BDNF signaling.

Hyun Soon Choi¹, Seong Hee Jeon², Hanyang Liu³, Minji Kim³, Jun Sang Yu⁴, Seung Sik Yoo⁴, Dong Ju Son⁴, Sang-Bae Han⁴, In Jun Yeo⁵, Sung Cil Lim⁶, Jin Tae Hong⁷

¹The Laboratory of Clinical Pharmacy, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of Korea.

²College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk 28160, Republic of Korea; Healthcare Convergence Educational Group for Infectious Disease Management, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.

³Healthcare Convergence Educational Group for Infectious Disease Management, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.

⁴College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk 28160, Republic of Korea.

⁵Healthcare Convergence Educational Group for Infectious Disease Management, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address: brightline@knu.ac.kr.

⁶The Laboratory of Clinical Pharmacy, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi-do 14662, Republic of Korea. Electronic address: lim5@catholic.ac.kr.

⁷College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk 28160, Republic of Korea. Electronic address: jinthong@chungbuk.ac.kr.

PubMed DOI

Abstract

The tumor suppressor protein p53 is a known modulator of neurodegenerative disease (ND) processes. Although p53 expression is increased in the brains of patients with Alzheimer's disease, Parkinson's disease, and ischemic stroke, its role in mood disorders such as anxiety and depression remains unclear. To investigate the role of p53 in behavioral responses to chronic stress, we examined behaviora…

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