Antidepressant Use During Pregnancy and Birth Outcomes: Analysis From the UK, Norway, and Sweden.

Florence Z Martin^1,2,3,4,5, Viktor H Ahlqvist^1,6,7, Paul Madley-Dowd^1,2,3,8, Michael Lundberg⁹, Jacqueline M Cohen^4,10, Kari Furu^4,10, Dheeraj Rai^1,2,3,8, Harriet Forbes¹¹, Kayleigh Easey^1,12, Siri E Håberg⁴, Gemma C Sharp^1,13, Cecilia Magnusson⁹, Maria C Magnus^1,4

¹MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

²Population Health Sciences, University of Bristol, Bristol, UK.

³Centre for Academic Mental Health, University of Bristol, Bristol, UK.

⁴Centre for Fertility and Health, Norwegian Institute for Public Health, Oslo, Norway.

⁵Epidemiology and Scientific Strategy, IQVIA, London, UK.

⁶Department of Biomedicine, Aarhus University, Aarhus, Denmark.

⁷Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden.

⁸NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK.

⁹Department of Global Public Health, Karolinska Institutet, Solna, Sweden.

¹⁰Department of Chronic Diseases, Norwegian Institute for Public Health, Oslo, Norway.

¹¹Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

¹²Department of Psychological Science, University of Bristol, Bristol, UK.

¹³Department of Psychology, University of Exeter, Exeter, UK.

PubMed DOI

Abstract

PURPOSE: Although antidepressant use during pregnancy has been linked to adverse birth outcomes such as stillbirth and preterm delivery, existing evidence is conflicting and rarely presents absolute risk estimates. We aimed to assess the association between antidepressant use during pregnancy and birth outcomes, alongside estimates of absolute risk to aid clinical interpretation. METHODS: We cond…

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