Brain pro-resolving-to-pro-inflammatory lipids and cPLA2 activation associations with late-life cognitive trajectories.

Anat Yaskolka Meir¹, Xinhui Wang², Boyang Li², Robert S Wilson³, David A Bennett³, Stan G Louie⁴, Hussein N Yassine², Zoe Arvanitakis⁵

¹Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

²Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

³Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

⁴Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA.

⁵Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. Electronic address: Zoe_Arvanitakis@rush.edu.

PubMed DOI

Abstract

BACKGROUND: Lipidome alterations are linked to neurodegenerative disorders, but the association between calcium-dependent phospholipase A2 (cPLA2)-related lipid ratios, which reflect pro-resolving and pro-inflammatory lipid biology, and age-related cognitive decline remains unclear. METHODS: In postmortem dorsolateral prefrontal cortex samples from participants in the Religious Orders Study and t…

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