Peer-Reviewed Publication
J Alzheimers Dis2026;13872877261470393.August 12, 2026Journal Article
Risk factors and cognitive domain markers of progression in subjective cognitive decline.
Omonigho M Bubu1,2,3,4,5, Alfred K Mbah6, Mark A Bernard1,3, Anthony Briggs1,3, Arline Faustin1,7, Lindsey Gurin1,2,3, Julia A Rao1,3, Sakina Ouedraogo Tall1,8, Ricardo S Osorio1,2,5, Arjun V Masurkar1,3,9
1NYU Alzheimer's Disease Research Center, NYU Grossman School of Medicine, New York, NY, USA.
2Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
3Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
4Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
5Center for Sleep and Brain Health, NYU Grossman School of Medicine, New York, NY, USA.
6Cytel Inc,, Cambridge, MA, USA.
7Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.
8Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA.
9Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA.
Abstract
BackgroundSubjective cognitive decline (SCD) is increasingly recognized in some cases as an early clinical stage in the Alzheimer's disease continuum, yet the factors that predict which individuals will progress to objective impairment remain poorly understood.ObjectiveWe evaluated risk factor differences and cognitive domain markers associated with progression in participants with subjective cogn…
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