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Peer-Reviewed Publication
Diagnosis (Berl)2026August 13, 2026Journal Article

Enhancing diagnostic safety: addressing knowledge gaps for using human factors tools in the safe and effective use of AI - a proposed research agenda.

Emily S Patterson1, Grayson L Baird2, David Bates3, Jeff Brady4, Kenneth R Catchpole5, Linda Gangai6, Mark Graber7, Ayse P Gurses8, Charles E Kahn9, Elizabeth A Krupinski10, Soundar Kumara11, Chris Mamrol12, Kristen E Miller13, Timothy J Mosher14, Sarah E Parker15, Mary D Patterson16, Susan Shelmerdine17, Joshua Streit18, Charlotte van Sassen19, Michael H Kanter20, Melissa Carraway21, Michael A Bruno14
1Department of Mechanical and Industrial Engineering, Marieb Center for Nursing and Engineering Innovation, University of Massachusetts Amherst, Amherst, MA, USA.
2Department of Radiology, Brown University Health and Warren Alpert Medical School, Brown University, Providence, RI, USA.
3Department of Medicine, Harvard University, Boston, MA, USA.
4Independent Healthcare Expert and Consultant, Rockville, MD, USA.
5Department of Anesthesia and Perioperative Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
6Department of Emergency Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
7Department of Medicine, Stony Brook University, New York, US; and Community to Improve Diagnosis, Plymouth, MA, USA.
8Armstrong Institute Center for Health Care Human Factors and Anesthesiology and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
9Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
10Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA, USA.
11Department of Information Sciences and Technology, Penn State University, College Park, PA, USA.
12Pennsylvania Patient Safety Authority, Harrisburg, PA, USA.
13Department of Emergency Medicine, National Center for Human Factors in Healthcare, Medstar Health, Georgetown University, Washington, DC, USA.
14Department of Radiology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
15Department of Health Systems and Implementation Science, Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
16Department of Emergency Medicine, University of Florida Gainesville, Gainesville, FL, USA.
17Department of Radiology, Great Ormond Street Hospital, London, UK.
18Aidoc, Plain City, OH, USA.
19Institute of Medical Education Research Rotterdam (iMERR), Erasmus, Netherlands.
20Kaiser-Permanente Bernard J. Tyson School of Medicine and the Southern California Permanente Medical Group, Pasadena, CA, USA.
21University of Maryland, Baltimore, MD, USA.

Abstract

INTRODUCTION: Identify knowledge gaps in applying artificial intelligence in clinical settings, using medical imaging as a primary use case to enhance diagnostic efficacy, efficiency, and patient and provider safety. METHODS: We convened a two-day workshop with 18 interdisciplinary experts from three countries. Experts represented quality and patient safety, human factors and systems engineering,…

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