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Peer-Reviewed Publication
J Pathol Clin Res2026;12(5):e70112.September 1, 2026Journal Article

Increased CCR5 expression in lymphoma cells and M2 macrophages is associated with poor prognosis in primary intestinal diffuse large B-cell lymphoma.

Wei-Li Ma1,2, Tsai-Yun Chen3, Pei-An Fu3, Jo-Pai Chen4, Ming Yao5, Hsiu-Po Wang6, Been-Ren Lin7, Chung-Wu Lin8,9, Chia-Lang Hsu10, Chung-Yu Huang11, Ann-Lii Cheng1,2,12, Sung-Hsin Kuo1,2,13
1Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
2Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.
3Division of Hematology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
4Department of Oncology, National Taiwan University Hospital, Yunlin Branch, Douliu, Taiwan.
5Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
6Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
7Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
8Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
9Department of Pathology and Laboratory Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
10Department of Medical Research, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
11Medical Informatics Division, ACT Genomics Co. Ltd, Taipei, Taiwan.
12Department of Medical Oncology, National Taiwan University Cancer Center, National Taiwan University College of Medicine, Taipei, Taiwan.
13Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan.
PubMed DOI

Abstract

Few studies have evaluated the impact of organ-specific tumor microenvironments (TMEs) on clinical outcomes in diffuse large B-cell lymphoma (DLBCL). This study investigated potential molecular markers, the immune cell composition within the TME, and their associations with clinical outcomes in patients with primary intestinal DLBCL (PI-DLBCL). We initially analyzed RNA expression in tumor cells f…

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