Peer-Reviewed Publication
Neurocrit Care2026August 11, 2026Journal Article
Associations and Predictive Value of Neuroimaging Characteristics for Extubation Failure in Moderate to Severe Traumatic Brain Injury: An Exploratory Analysis.
Ali Abu-Alya1, Aaron Gallagher2, Wenxuan Xiong2,3, Eliza Baird-Daniel3, Shauna Carlson4, Christine Fong5, Adrienne James5, Chiara Robba6, Shaurya Taran7, Monisha Sharma8, Abhijit V Lele2,3,5, Robert H Bonow3, James A Town9, Sarah Wahlster2,3,5
1Department of Neurology, University of Washington, Seattle, WA, USA. aliabualya@icloud.com.
2Department of Neurology, University of Washington, Seattle, WA, USA.
3Department of Neurological Surgery, University of Washington, Seattle, WA, USA.
4Harborview Medical Center Trauma Program, Seattle, WA, USA.
5Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
6Department of Surgical Science and Integrated Diagnostic, University of Genoa, Genoa, Italy.
7Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
8Department of Global Health, University of Washington, Seattle, WA, USA.
9Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
Abstract
BACKGROUND: Predicting successful extubation in traumatic brain injury (TBI) remains challenging. We examined associations between structural neuroimaging characteristics and extubation failure in TBI, and the ability to enhance prognostic models based on clinical characteristics alone.
METHODS: Retrospective cohort study of patients with moderate-severe TBI [Glasgow Coma Scale (GCS) ≤ 12] who we…
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