Health AI Central
Peer-Reviewed Publication
Circulation2026August 11, 2026Journal Article

Opportunistic Screening for Chagas Disease Using an Artificial Intelligence-Enabled ECG: Prospective Evaluation of Feasibility and Diagnostic Accuracy.

Antonio Luiz Pinho Ribeiro1, Clareci Silva Cardoso2, Cesar Augusto Taconeli3, Cláudia Di Lorenzo Oliveira2, Paulo Rodrigues Gomes4, Lea Campos Oliveira-da Silva5, Ariela Mota Ferreira6, Nayara Dornela Quintino7, Nayara Ragi Baldoni2,8, Ana Carolina de Oliveira Gonçalves2, Wanessa Campos Vinhal2, Dardiane Santos Cruz6, Sâmara Fernandes Leite6, Ana Clara de Jesus Santos6, Letícia de Azevedo Silva9, Fernanda Alvarenga Cardoso Medeiros9, Mayara Santos Mendes4, Israel Molina10,11, Maria Carmo Pereira Nunes1, Thomas B Schön12, Antonio Horta Ribeiro12,13, Ester Cerdeira Sabino14
1Department of Internal Medicine, School of Medicine, Telehealth Center, and Cardiology Service (A.L.P.R., M.C.P.N.), Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
2Federal University of São João del-Rei, Divinópolis, Minas Gerais, Brazil (C.S.C., C.D.L.O., A.C.d.O.G., W.C.V., N.R.B.).
3Federal University of Paraná, Curitiba, Brazil (C.A.T.).
4Telehealth Center (P.R.G., M.S.M.), Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
5Laboratório de Genética de Microorganismos Aplicada a Medicina, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil (L.C.O.-d.S.).
6State University of Montes Claros, Minas Gerais, Brazil (A.M.F., D.S.C., S.F.L., A.C.d.J.S.).
7State Department of Health, Divinópolis, Minas Gerais, Brazil (N.D.Q.).
8University of Itaúna, Minas Gerais, Brazil (N.R.B.).
9Fundação Ezequiel Dias, Instituto Octávio Magalhães, Serviço de Doenças Parasitárias, Belo Horizonte, Minas Gerais, Brazil (L.d.A.S., F.A.C.M.).
10Infectious Diseases Department and International Health Unit, Vall d'Hebron University Hospital, Barcelona, Spain (I.M.).
11Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain (I.M.).
12Department of Information Technology, Uppsala University, Sweden (T.B.S., A.H.R.).
13Science for Life Laboratory, Uppsala, Sweden (A.H.R.).
14Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, Brazil (E.C.S.).
PubMed DOI

Abstract

BACKGROUND: Chagas disease (ChD), a neglected cardiovascular condition, affects 7.5 to 10.5 million people worldwide. Opportunistic screening during routine electrocardiography may allow earlier detection of unrecognized infections, enabling timely antiparasitic therapy or optimized cardiac care. This study prospectively evaluated the feasibility and diagnostic accuracy of an artificial intelligen…

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