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Peer-Reviewed Publication
Psychol Med2026;56e257.August 10, 2026Journal Article

Anxiety and depression subtypes and their psychotherapy response: A network analysis of 33,675 patients.

Zoë Mermin1, Donald J Robinaugh2,3,4, Thomas D Hull5, Kristin L Szuhany1, Naomi Simon1, Matteo Malgaroli1,6
1Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.
2Department of Applied Psychology, Northeastern University, Boston, MA, USA.
3Department of Art + Design, Northeastern University, Boston, MA, USA.
4Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
5Talkspace, New York, NY, USA.
6New York University Center for Data Science, New York, NY, USA.
PubMed DOI

Abstract

BACKGROUND: Major depressive disorder and generalized anxiety disorder frequently co-occur, leading to heterogeneous presentations that complicate diagnosis and treatment. While diagnostic categories often obscure symptom variability, network approaches offer a powerful way to examine how symptoms relate to one another within and across conditions. By identifying symptom clusters, these methods ca…

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