Single-cell transcriptome-guided biomimetic magnetothermal hydrogel microspheres for multimodal eradication of residual glioblastoma.

Nan Wu^1,2, Xi Luan², Bihe Yuan³, Mingyuan Xia⁴, Jianliang Shen², Jing Lin^2,5, Lixia Xu^1,6, Hai Lin², Lexiang Zhang^2,5,7, Fangfu Ye^2,8, Hua Yan^1,6,9

¹Department of Neurosurgery, Huanhu Hospital Affiliated to Tianjin Medical University, Tianjin Medical University, Tianjin, 300070, PR China.

²Zhejiang Key Laboratory of Soft Matter Biomedical Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, PR China.

³School of Physical Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, PR China.

⁴School of Materials Science and Engineering, Central South University, Changsha, Hunan, 410083, PR China.

⁵Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, PR China.

⁶Tianjin Key Laboratory of Cerebral Blood Flow Reconstruction and Head and Neck Tumor New Technology Translation, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, 300350, PR China.

⁷Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, PR China.

⁸Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, PR China.

⁹Tianjin Fourth Central Hospital, The Affiliated Hospital of Tianjin Medical University, Tianjin, 300140, PR China.

PubMed PMC DOI PDF

Abstract

Incomplete resection and rapid postoperative recurrence remain major challenges in glioblastoma (GBM) treatment. Inspired by the self-healing microduct architecture of pine resin, we developed an injectable magnetothermal-responsive hierarchical hydrogel microsphere platform, HGM + Multi(+), for spatiotemporally programmed magnetothermal ablation, anti-angiogenic blockade, and targeted chemotherap…

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