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Contemp Clin Trials Commun2026;53101669.October 1, 2026Journal Article

Recruitment strategies in the PROMISE Registry: Evaluating institutional outreach, direct-to-patient marketing, and community engagement approaches in a decentralized germline genetic registry.

Channing J Paller1, Ken Freitas2, Natalie Macario3, Christina Tran3, Kelly Faville2, Kathy Wiedemer2, Jenny Chiang2, Justin Lorentz4, Leonard J Appleman5, Andrew J Armstrong6, Pedro C Barata7, Hala T Borno8,9, Keith Crawford10, Tiffani A DeMarco11, Robert Dreicer12, Jo Ann B Elrod13, Sheryl Gabram14, Christopher George15, Elisabeth I Heath16, Arif Hussain17, Maha H A Hussain15, Jordan M Neil18, Shifeng Mao19, Rana R McKay20, Alicia K Morgans21, Motolani E Ogunsanya18, Matthew Orton22, Ted Ritchie23, Biren Saraiya24, Alexandra O Sokolova25, Russell Szmulewitz26, Imani Fortt3, Leezandra Ramos3, Stormi Smith3, Patrick Freeman3, Amanda McMannis3, Rebecca Green3, Jacob Vinson3, Heather H Cheng27,28
1Johns Hopkins University School of Medicine, Baltimore, MD, USA.
2Advancing Cancer Treatment, McLean, Virginia, USA.
3Prostate Cancer Clinical Trials Consortium, New York, NY, USA.
4Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
5University of Pittsburgh Hillman Cancer Center, Pittsburgh, PA, USA.
6Duke Cancer Institute Center for Prostate & Urologic Cancers, Durham, NC, USA.
7University Hospitals Seidman Cancer Center, Cleveland, OH, USA.
8Trial Library, San Francisco, CA, USA.
9University of California, San Francisco, CA, USA.
10Prostate Health Education Network Inc., Quincy, MA, USA.
11Inova Schar Cancer Institute, Fairfax, VA, USA.
12University of Virginia Comprehensive Cancer Center, Charlottesville, VA, USA.
13Seattle Cancer Care Alliance, Seattle, WA, USA.
14Georgia Center for Oncology Research and Education, Atlanta, GA, USA.
15Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
16Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA.
17University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
18TSET Health Promotion Research Center, Stephenson Cancer Center, University of Oklahoma Health Campus, Oklahoma City, OK, USA.
19Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.
20University of California San Diego, La Jolla, CA, USA.
21Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
22Indiana University Health Arnett Cancer Center, Lafayette, IN, USA.
23Urology Clinics of North Texas, Dallas, TX, USA.
24Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
25Oregon Health & Science University Knight Cancer Institute, Portland, OR, USA.
26University of Chicago, Chicago, IL, USA.
27University of Washington, Seattle, WA, USA.
28Fred Hutchinson Cancer Center, Seattle, WA, USA.
PubMed PMC DOI PDF

Abstract

PURPOSE: The PROMISE Registry is a U.S. decentralized, 20-year prospective prostate cancer germline genetic registry. Here, we examine the effectiveness of different recruitment strategies, including institutional partnerships, direct-to-patient marketing outreach, and community engagement grants (CEGs). METHODS: Recruitment efforts were categorized into: (1) Institutional outreach through physic…

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