Peer-Reviewed Publication
NMR Biomed2026;39(9):e70372.September 1, 2026Journal Article
Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas.
Capucine Cadin1, Stefano Casagranda2, François Xavier Lejeune3, Marianne Golse4, Bertrand Mathon1,5, Ottavia Dipasquale2, Christos Papageorgakis2, Mauro Zucchelli2, Emmanuel Mandonnet6,7, Stéphane Lehéricy4,8, Franck Bielle1, Marc Sanson1, Patrick Liebig9, Moritz Zaiss10, Lucia Nichelli4, Francesca Branzoli1
1Paris Brain Institute - ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, UMR S 1127, Equipe labellisée LNCC, Paris, France.
2Department of R&D Advanced Applications, Olea Medical, La Ciotat, France.
3Data Analysis Core, Paris Brain Institute, Paris, France.
4Department of Neuroradiology, La Pitié Salpêtrière Hospital, AP-HP, Paris, France.
5Department of Neurosurgery, La Pitié Salpêtrière Hospital, AP-HP Sorbonne University, Paris, France.
6Department of Neurosurgery, Lariboisière Hospital, AP-HP, Paris, France.
7Université de Paris Cité, Paris, France.
8Paris Brain Institute - ICM, Center for NeuroImaging Research - CENIR, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, UMR S 1127, Paris, France.
9Siemens Healthcare GmbH, Erlangen, Germany.
10Department of Neuroradiology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Abstract
Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion are key molecular markers for glioma classification. Amide proton transfer weighted (APTw) and nuclear Overhauser effect-weighted (NOEw) markers showed promise for glioma characterization, by probing protein-related tissue properties. However, their interpretation is confounded by direct water saturation, macromolecules (semi-solid magn…
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