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Peer-Reviewed Publication
Plast Reconstr Surg Glob Open2026;14(8):e7990.August 1, 2026Journal Article

Persistent Hyperpigmentation Following Coretox Injection: A Review of Adverse Events Associated with Polysorbate 20.

Jong Seo Kim1
1From the Botox-Filler-Thread Research Group, Korean Society of Plastic and Reconstructive Surgery (KPRS), Kim-JongSeo Plastic Surgery Clinic: 2F Apgujung BD, Seoul, Korea.
PubMed PMC DOI PDF

Abstract

Postprocedural hyperpigmentation is a rare but concerning complication after botulinum toxin type A injections. In 2024, 3 patients developed persistent facial hyperpigmentation following Coretox administration in the glabellar and forehead regions. This case series characterizes the clinical course, imaging findings, and hypothesized mechanisms underlying this reaction. Three female patients rece…

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