Peer-Reviewed Publication
Ann Clin Transl Neurol2026August 7, 2026Journal Article
Arterial Spin-Labeling MRI at the Cortical-CSF Interface: A Novel Biomarker in Alzheimer Disease.
Mona Asghariahmadabad1, Pouya Metanat1, Michael Thomas1, Luke W Bonham1, Tyson Lam2, Mehmet Kurt2, Hong Nguyen3, Tara Ellingson3, Mauro Zucchelli4, Stefano Casagranda4, Quin Lu5, Andreas M Rauschecker1, Leo Sugrue1, Luis E Savastano6, Christopher P Hess1, Kamalini Ranasinghe3, S Andrew Josephson3, Bruce L Miller3, Jennifer S Yokoyama1,3, Gil D Rabinovici3, Peter A Ljubenkov3, Lawren VandeVrede3, Kambiz Nael1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
2Department of Mechanical Engineering, University of Washington, Seattle, Washington, USA.
3Department of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.
4Department of Research and Innovation of Olea Medical, La Ciotat, France.
5GE HealthCare, San Francisco, California, USA.
6Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Abstract
BACKGROUND/OBJECTIVE: Arterial spin-labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF-adjacent water transport physiology. We developed an automated pipeline to extract cortical-CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal controls.
METHODS: In this retrospective study, participants…
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