Human neuronal cells SH-SY5Y as an in vitro model to study Neospora caninum infection and innate immune modulation.

Natalia Plá¹, Mercedes M Burucúa¹, Dadin P Moore², Eduardo R Cobo³, Anselmo C Odeón², Silvina Quintana⁴, Maia S Marin⁵

¹Departamento de Biología, Facultad de Ciencias Exactas y Naturales, UNMdP, Mar del Plata, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.

²Unidad Integrada Balcarce (Facultad de Ciencias Agrarias, UNMDP/Estación Experimental Agropecuaria Balcarce, INTA), Balcarce, Buenos, Argentina.

³Faculty of Veterinary Medicine, University of Calgary, Canada.

⁴Instituto de Investigaciones en Producción, Sanidad y Ambiente - IIPROSAM (CONICET-UNMdP), Facultad de Ciencias Exactas y Naturales-UNMdP, Centro Científico Tecnológico Mar del Plata-CONICET Centro de Asociación Simple CIC-PBA, Mar del Plata, Buenos Aires, Argentina; Instituto de Biología Molecular Aplicada, Mar del Plata, Buenos Aires, Argentina.

⁵Departamento de Biología, Facultad de Ciencias Exactas y Naturales, UNMdP, Mar del Plata, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address: marinmaia@mdp.edu.ar.

PubMed DOI

Abstract

Neospora caninum causes significant losses due to abortions in cattle worldwide. The parasite can establish persistent infections in the central nervous system (CNS). Innate immune recognition, primarily mediated by Toll-like receptors (TLRs), and the expression of cytokines and antimicrobial peptides, such as cathelicidins, during N. caninum infection in neuronal cells remains undefined. This wor…

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