Peer-Reviewed Publication
JACC Cardiovasc Imaging2026August 4, 2026Journal Article
Ultrasound Cavitation of Microbubbles Augments Limb Perfusion and Promotes Ulcer Healing in Chronic Limb-Threatening Ischemia.
Bethany A Gholson1, Matteo Morello1, Sofia Capdeville2, J Todd Belcik3, James Hodovan3, Yujin Choi1, Ruei-Jen Abraham-Fan1, Khanh P Nguyen4, Brian P Davidson5, Jeffry Powers6, Jonathan R Lindner7
1Cardiovascular Division, University of Virginia, Charlottesville, Virginia, USA; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA.
2Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA.
3Knight Cardiovascular Institute, Portland, Oregon, USA.
4Knight Cardiovascular Institute, Portland, Oregon, USA; Division of Vascular Surgery, Oregon Health & Science University, Portland, Oregon, USA; Portland Veterans Administration Health Care System, Portland, Oregon, USA.
5Knight Cardiovascular Institute, Portland, Oregon, USA; Portland Veterans Administration Health Care System, Portland, Oregon, USA.
6Philips Ultrasound, Bothell, Washington, USA.
7Cardiovascular Division, University of Virginia, Charlottesville, Virginia, USA; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA. Electronic address: jlindner@virginia.edu.
Abstract
BACKGROUND: In patients with peripheral artery disease and chronic limb-threatening ischemia (CLTI), there is a lack of effective treatment options when arterial revascularization is not feasible. In preclinical models, ultrasound (US) cavitation of microbubble contrast agents can augment limb perfusion through multiple shear-mediated vasoactive pathways.
OBJECTIVES: This study aims to evaluate w…
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