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Imaging Neurosci (Camb)2026;4January 1, 2026Journal Article

Bioinformed idiographic symptom networks to identify neurobiological predictors of affective-state transitions in bipolar disorder.

Siraj J Lyons1, John Foley1, Olivia Cook1,2, Brendan E Depue1,3
1Department of Psychological & Brain Sciences, University of Louisville, Louisville, KY, United States.
2Surgical Theater, Beachwood, OH, United States.
3Department of Anatomical Sciences & Neurobiology, University of Louisville, Louisville, KY, United States.
PubMed PMC DOI PDF

Abstract

Bipolar disorder remains an understudied psychiatric condition. Research has been focused on neurobiological mechanisms with the hope of identifying unique markers distinguishing bipolar disorder from similar conditions (i.e., major depressive disorder and schizophrenia), in addition to neurocognitive mechanisms driving affective state transitions. While these investigations continue to gain popul…

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