A magnetic resonance imaging analysis of cognitively discordant monozygotic and dizygotic twins: a comparative study of visual rating method and tensor-based morphometry.

Terhi Tuokkola^1,2, Riitta Parkkola^3,4, Juha Koikkalainen⁵, Tero Vahlberg⁶, Jaakko Kaprio⁷, Jyrki Lötjönen⁵, Vuoksimaa Eero⁷, Juha Rinne^2,4,8

¹Wellbeing Services County of Southwest Finland, Turku, Finland.

²Turku PET Centre, Turku University Hospital, Turku, Finland.

³Department of Radiology, Turku University Hospital, Turku, Finland.

⁴University of Turku, Turku, Finland.

⁵Combinostics Ltd, Tampere, Finland.

⁶Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.

⁷Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

⁸InFLAMES Research Flagship Center, University of Turku, Turku, Finland.

PubMed DOI

Abstract

BackgroundAtrophy of the medial temporal lobes and deep gray matter, along with ventricular enlargement, are typical structural magnetic resonance imaging (MRI) findings in the brains of patients with Alzheimer's disease (AD). However, there are few twin studies on this subject.PurposeTo determine whether the visual rating method (VRM) and tensor-based morphometry (TBM) can detect the structural b…

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