Peer-Reviewed Publication
JAMA Netw Open2026;9(8):e2627335.August 3, 2026Journal Article
Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia.
Zafar Zafari1,2, Mehdi Najafzadeh3, Mufaddal Mahesri4, HoJin Shin4, Philip P Goodney5, Michael S Conte6, Mark A Creager5, Michael D Dake7, John A Kaufman8, Richard J Powell5, Chris J White9, Michael B Strong10, Kenneth Rosenfield11, Alik Farber12, Matthew T Menard10, Niteesh K Choudhry4
1University of Maryland Institute for Health Computing, Bethesda.
2Department of Practice, Sciences, and Health Outcomes Research, University of Maryland School of Pharmacy, Baltimore.
3Medidata Solutions, Boston, Massachusetts.
4Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
5Heart and Vascular Center, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
6Division of Vascular and Endovascular Surgery, University of California, San Francisco.
7Department of Medical Imaging, University of Arizona Health Sciences, Tucson.
8Division of Interventional Radiology, Oregon Health & Science University, Portland.
9Department of Cardiovascular Diseases, The Ochsner Clinical School, New Orleans, Louisiana.
10Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
11Section of Vascular Medicine and Intervention, Massachusetts General Hospital, Harvard Medical School, Boston.
12Division of Vascular and Endovascular Surgery, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
Abstract
IMPORTANCE: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice.
OBJECTIVE: To evaluate the cost-effectiveness of endovascular vs bypass surgical revascularization.
DESIGN, SETTING, AND PARTICIPANTS: This economic evaluation used individual-level data from the Best Endovascular vs Best Surgi…
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