Advanced algorithm for correcting cold agglutination interference in red blood cell parameters with the Mindray BC-7600 hematology analyzer.

Bo Ye¹, Jiong Zhang², Wenbo Zheng³, Danzhou Tao⁴, Zhongfu Zhang⁵, Yushuai Ma⁵, Taiqiang Zhao⁶

¹Department of Clinical Research & Medical Affairs, Shenzhen Mindray Bio-Medical Electronic Co. Ltd., Shenzhen, China. Electronic address: yebo@mindray.com.

²Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.

³Department of Clinical Research & Medical Affairs, Shenzhen Mindray Bio-Medical Electronic Co. Ltd., Shenzhen, China. Electronic address: zhengwenbo@mindray.com.

⁴Department of Clinical Research & Medical Affairs, Shenzhen Mindray Bio-Medical Electronic Co. Ltd., Shenzhen, China. Electronic address: taodanzhou@mindray.com.

⁵Department of Clinical Research & Medical Affairs, Shenzhen Mindray Bio-Medical Electronic Co. Ltd., Shenzhen, China.

⁶Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China. Electronic address: zhaotaiqiang@med.uestc.edu.cn.

PubMed DOI

Abstract

OBJECTIVE: To develop an advanced algorithm for correcting spurious RBC parameters in cold agglutination (CA) samples, and evaluate the performance of the algorithm and explore its clinical applications. METHODS: RBC-specific antibodies were added to blood samples at different dilution ratios to simulate CA samples. On the difference of the RBC aggregates histogram between CA and normal, degree o…

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