Peer-Reviewed Publication
Lancet Infect Dis2026July 28, 2026Journal Article
Effectiveness of scabies treatments in Italy (SCAB-net): a prospective observational study.
Tommaso Ioris1, Francesca Fortunato2, Michela Magnano3, Corrado Zengarini4, Giulia Rech1, Salvatore Domenico Infusino1, Andrea Michelerio5, Claudio Guarneri6, Joele Cartini7, Roberta Giuffrida7, Andrea Bassi8, Carlo Mazzatenta8, Iria Neri9, Martina Mussi4, Ilaria Trave10, Riccardo Castelli11, Federica Scarfì12, Franca Taviti12, Andrea Carugno13, Teresa Oranges14, Cesare Filippeschi14, Luigi Pisano15, Martina Turco16, Paola Coppo17, Roberta La Selva17, Giuseppe Stinco18, Enzo Errichetti18, Sebastiano Recalcati19, Giulia Ciccarese20, Marco Galluzzo21, Gianluca Nazzaro22, Stefano Ramoni23, Emanuele Trovato24, Stefano Caccavale25, Caterina Mariarosaria Giorgio25, Paola Sgubbi26, Michela Tabanelli26, Francesco Bellinato27, Nicolò Rivetti28, Elisa Zavattaro29, Domenico Bonamonte30, Andrea Gustavo Locatelli31, Giuseppe Argenziano25, Laura Atzori32, Manuela Papini33, Riccardo Balestri1,
1Division of Dermatology, STI Outpatient Service, Azienda Sanitaria Universitaria Integrata del Trentino (ASUIT), Trento Hospital, Trento, Italy.
2Hygiene Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
3Unit of Dermatology, Azienda USL Toscana Nord Ovest, Lucca, Italy. Electronic address: michela.magnano@gmail.com.
4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
5SC Dermatologia, Ospedale Cardinal Massaia, Asti, Italy; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
6Section of Dermatology, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
7Dermatology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
8Unit of Dermatology, Azienda USL Toscana Nord Ovest, Lucca, Italy.
9Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
10Section of Dermatology, Department of Health Sciences, University of Genoa, Genoa, Italy; IRCCS Azienda Ospedaliera Metropolitana, Ospedale Policlinico San Martino, Genoa, Italy.
11Section of Dermatology, Department of Health Sciences, University of Genoa, Genoa, Italy; Section of Dermatology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
12SOC Dermatologia Prato Pistoia, Ospedale Santo Stefano, Prato, Italy.
13Department of Medicine and Surgery, University of Insubria, Varese, Italy.
14Dermatology Unit, Meyer Children's Hospital, IRCCS, Florence, Italy.
15Centro MTS, SC Dermatologia, Ospedale Piero Palagi, USL Toscana Centro, Florence, Italy.
16Dipartimento di Scienze della Salute, Università degli Studi di Firenze, Florence, Italy.
17SSVD Chirurgia Plastica Pediatrica, Dermatologia Pediatrica Ospedale Infantile Regina Margherita, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Turin, Italy.
18Institute of Dermatology, Department of Medicine, University of Udine, Udine, Italy.
19Dermatology Unit, ASST Lecco, Alessandro Manzoni Hospital, Lecco, Italy; Dermatology Unit, ASST Lariana, Sant'Anna Hospital, Como, Italy.
20Dipartimento di Scienze Mediche e Chirurgiche, Università degli studi di Foggia, Foggia, Italy.
21Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy; Dermatology Unit, Azienda Ospedaliera Universitaria Policlinico Tor Vergata, Rome, Italy.
22SC Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.
23SSD IST, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
24Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
25University of Campania Luigi Vanvitelli, Naples, Italy.
26Dermatologic Unit, Department of Surgery, Santa Maria delle Croci Hospital of Ravenna, AUSL Romagna, Ravenna, Italy.
27Sezione di Dermatologia e Venereologia, Dipartimento di Medicina, Università di Verona, Verona, Italy.
28Dermatology Outpatient Clinic, Istituto Clinico Beato Matteo, Gruppo San Donato, Vigevano, Italy.
29Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
30Unit of Dermatology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, Bari, Italy.
31Dermatology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
32Unit of Dermatology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
33Dipartimento di Medicina e Chirurgia, Università di Perugia, Perugia, Italy.
Abstract
BACKGROUND: Scabies is a neglected tropical disease with a worldwide distribution. Although uncommon in high-income countries, its incidence has increased in recent years, accompanied by growing reports of treatment failure, particularly with topical permethrin. Observational data from high-income settings remain scarce. We aimed to evaluate the effectiveness of first-line scabies treatments and t…
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