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Peer-Reviewed Publication
Menopause2026July 28, 2026Journal Article

Psychological symptoms during perimenopause: a global perspective.

Adam C Cunningham1, Mary S Hedges2, Yella Hewings-Martin1, Regina Castaneda2,3, Jana Karam2,3, Liudmila Zhaunova1, Stephanie S Faubion2,3, Chrisandra L Shufelt2,3
1Flo Health, Inc., London, United Kingdom.
2Department of Medicine, Mayo Clinic, Jacksonville, FL.
3Center for Women's Health, Mayo Clinic, Rochester, MN.
PubMed DOI

Abstract

OBJECTIVES: Psychological health changes are known to occur during perimenopause, but the extent to which these differ from premenopause remains unclear. This study aimed to assess psychological symptoms during perimenopause compared with premenopause and evaluate differences by country. METHODS: Flo app users aged 35 years or above not taking hormonal contraception or hormone therapy were includ…

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