Right ventricular remodeling and circulating metabolic profiles of patients with chronic thromboembolic pulmonary hypertension before and after pulmonary endarterectomy.

Samantha Guimaron^1,2, Julia Mercier², Thaïs Hautbergue³, Grégoire Ruffenach^1,2, Myriam Amsallem^2,4, Laurent Savale^1,2,5, Agathe Potier⁶, Estelle Blanc⁷, Anvi-Laëtitia Nguyen³, François Fenaille³, Benoit Colsch³, Marc-Antoine Isorni⁶, Peter Dorfmüller², Lilia Lamrani⁸, Mélanie Lambert², Philippe Deleuze⁹, Xavier Jais^1,2,5, Jérôme Le Pavec^1,2,8, Christophe Junot³, Marc Humbert^1,2,5, Laurence Mabille⁷, Elie Fadel^1,2,8, François Haddad⁴, Julien Guihaire^1,2,9, Fabrice Antigny^1,2, Olaf Mercier^1,2,9,

¹Université Paris-Saclay, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique (HPPIT), Faculté de Médecine, Le Kremlin-Bicêtre, France.

²INSERM UMR_S 1358, HPPIT, Hôpital Marie Lannelongue, FHU André Cournand, Le Plessis-Robinson, Paris, France.

³Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la santé, MetaboHUB, Gif-sur-Yvette 91191, France.

⁴Division of Cardiovascular Medicine, Stanford University, California, CA.

⁵Department of Respiratory and Intensive Care Medicine, Assistance Publique-Hôpitaux de Paris (AP-HP), ERN-LUNG, Pulmonary Hypertension National Referral Center, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

⁶Department of Cardiology, Marie Lannelongue Hospital, Le Plessis Robinson, France.

⁷Department of Nuclear Medicine and Radiology, Marie Lannelongue Hospital, Le Plessis Robinson, France.

⁸Department of Thoracic Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Le Plessis Robinson, France.

⁹Department of Adult Cardiac Surgery, Marie Lannelongue Hospital, Le Plessis Robinson, France.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Right ventricular (RV) adaptation to chronic thromboembolic pulmonary hypertension (CTEPH) remains incompletely understood. Precise phenotyping of RV reverse remodeling after pulmonary endarterectomy (PEA) may help identify biomarkers and generate hypotheses for future mechanistic and therapeutic studies on RV. We aimed to assess longitudinal changes in RV imaging, histology, and circu…

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