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Peer-Reviewed Publication
Lancet Reg Health Am2026;62101577.October 1, 2026Journal Article

Methadone treatment and associated health and social outcomes after a national manufacturing closure in Mexico: a longitudinal observational cohort study in Tijuana.

Jesse Lloyd Goldshear1, Alicia Harvey-Vera1, Gudelia Rangel2, Daniela Abramovitz1, Natasha K Martin1, Steffanie A Strathdee1, Joseph Friedman3, Maria Elena Medina-Mora4, Annick Bórquez1
1Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
2El Colegio de la Frontera Norte, Carretera Escenica Tijuana-Ensenada Toll Boot Escenica Tijuana-Ensenada Sn San Antonio del Mar, Tijuana, BC 22560, Mexico.
3Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
4Unidad de Apoyo a la Salud Emocional y Psicológica, Secretaria de Servicio y Atención a la Comunidad Universitaria, Universidad Nacional Autónoma de México, Center for Global Mental Health Research National Institute of Psychiatry RFM/UNAM, Mexico.

Abstract

BACKGROUND: Medications for opioid use disorder (MOUD) are key to the prevention of drug overdose and bloodborne infections among people with OUD while also improving psycho-social wellbeing. From February to August 2023, following government orders, Psicofarma, Mexico's primary methadone production facility remained closed, interrupting its supply nationwide. We aimed to explore associations betw…

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