Evaluation of 9-Minute Dual-Energy Peak Time-Reduced 360° CZT Total-Body [177Lu]Lu-PSMA SPECT/CT Imaging with Comparisons to [68Ga]Ga-PSMA PET.

Caroline Boursier^1,2, Sébastien Heyer^1,2, Abdelaali Zouaoui¹, Nathaniel Roth³, Raphael Blum³, Marine Claudin¹, Pierre Olivier¹, Pierre-Yves Marie^1,2, Antoine Verger^1,2, Laetitia Imbert^4,2

¹CHRU-Nancy, Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, Nancy, France.

²INSERM, IADI U1254, Université de Lorraine, Vandœuvre-lès-Nancy, France; and.

³Spectrum Dynamics Medical, Caesarea, Israel.

⁴CHRU-Nancy, Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, Nancy, France; l.imbert@chru-nancy.fr.

PubMed DOI

Abstract

Eighteen-minute 360° cadmium zinc telluride (CZT) total-body 177Lu-labeled SPECT acquisitions on the single 113-keV 177Lu photopeak (SP-18) have been reported to be suitable for monitoring [177Lu]Lu-PSMA therapy. This study evaluated dual-energy 113- and 208-keV acquisitions with a more than 2-fold increase in acquired counts, allowing acquisition time to be reduced to 9 min (DP-9). Methods: In 20…

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