Peer-Reviewed Publication
Eur Heart J Digit Health2026;7(6):ztag110.July 1, 2026Journal Article

The current state of artificial intelligence-based invasive coronary angiography image analysis: a systematic review.

Viktor O van der Valk1, Wouter P M van der Loo2, Nico Bruining3, Jouke Dijkstra1, Douwe E Atsma2, Marius Staring1, Roderick W C Scherptong2
1Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
2Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
3Thoraxcenter, Erasmus MC Rotterdam, Dr. Molenwaterplein 40, 3015 GD Rotterdam, The  Netherlands.

Abstract

Invasive coronary angiography (ICA) is the reference standard for diagnosing coronary artery disease and guiding percutaneous coronary intervention, yet clinical interpretation relies largely on visual assessment, which is variable and often requires additional invasive testing to assess functional significance. Artificial intelligence (AI)-based analysis of ICA images has emerged as a potential s…

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