Peer-Reviewed Publication
Hum Genomics2026July 21, 2026Journal Article
ExposoGenomics: integrating genome and exposome as jointly dynamic systems for causal discovery and precision health.
Vasilis Vasiliou1, Nicholas Katsanis2, Giuseppe Novelli3, Juergen K V Reichardt4, Bassam R Ali5, Maria Gazouli6, Sek Won Kong7,8, Hongyu Zhao9, Kiril Veselkov10,11, Bhramar Mukherjee9, Dimosthenis Sarigiannis10,12,13,14
1Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA. vasilis.vasiliou@yale.edu.
2Galatea Bio, Miami, FL, and Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece.
3Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy.
4Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, QLD, Australia.
5Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
6Department of Basic Medical Science, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
7Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.
8Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
9Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
10Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
11Department of Surgery and Cancer, Imperial College London, London, UK.
12Center of Excellence on Cancer Theranostics, National Hellenic Research Foundation, Athens, Greece.
13Environmental Engineering Lab, School of Chemical Engineering, and HERACLES Research Center on Health and the Exposome, Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, Thessaloniki, Greece.
14Department of Urology, Medical School, Johns Hopkins University, Baltimore, MD, USA.
Abstract
The past decade has witnessed an unprecedented convergence of exposomic technologies, population-scale genomics, and AI-enabled data science, creating the conditions for a new integrative discipline. Here we introduce ExposoGenomics, defined as the integrative study of how the genome and exposome, treated as jointly dynamic systems, interact across the life course to shape health and disease. Expo…
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