Antibiotic intervention reshapes gut microbiome and modulates deoxynivalenol-induced gut - liver axis disturbances.

Fangfang Li¹, Yafan Hu², Bowen Tai², Bingxin Huangfu³, Xiaoyun He³, Zipei Zhang⁴, Ruojie Zhang⁴, Jing Jin⁵, Fuguo Xing⁶

¹Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China; Laboratory for Precisely Designed Smart Food, Food Science Program, Division of Food, Nutrition & Exercise Sciences, University of Missouri, Columbia, Missouri, 65201, USA.

²Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China.

³Key Laboratory of Precision Nutrition and Food Quality, Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, Department of Nutrition and Health, China Agricultural University, Beijing 100083, PR China.

⁴Laboratory for Precisely Designed Smart Food, Food Science Program, Division of Food, Nutrition & Exercise Sciences, University of Missouri, Columbia, Missouri, 65201, USA.

⁵Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China. Electronic address: jinjing@caas.cn.

⁶Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, P. R. China. Electronic address: xingfuguo@caas.cn.

PubMed DOI

Abstract

Deoxynivalenol (DON) is a prevalent foodborne mycotoxin, and its toxicity is closely associated with gut-liver axis dysfunction. However, the role of antibiotic-induced gut microbiome modulation in DON-induced intestinal and hepatic injury remains unclear. In this study, mice were exposed to DON with or without antibiotic (ABX) treatment for 4 weeks to investigate the contribution of gut microbiom…

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