Formulation development and preliminary biological evaluation of a menthol modified thermoresponsive tamoxifen sol-gel.

Saleha Faheem¹, Huma Hameed², Sami A Al-Hussain³, Ali Irfan⁴, Shazia Akram Ghumman⁵, Magdi E A Zaki⁶

¹Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, 54000, Pakistan.

²Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, 54000, Pakistan. huma.hameed@ucp.edu.pk.

³Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia.

⁴The Green Institute of Chemical Biomedical and Environmental Sciences (GICBES), Lahore, 54000, Pakistan.

⁵College of Pharmacy, University of Sargodha, Sargodha, 40100, Pakistan.

⁶Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623, Riyadh, Saudi Arabia. mezaki@imamu.edu.sa.

PubMed DOI

Abstract

Localized drug delivery strategies offer potential advantages in improving therapeutic concentration at tumor sites while minimizing systemic exposure. In this study, a thermoresponsive poloxamer based sol-gel system incorporating tamoxifen citrate with L-menthol was developed and characterized for potential intratumoral application. The formulation was prepared using the cold method and optimized…

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