Toward Next-Generation Propellants: Assessing Lung Deposition of Beclometasone Dipropionate, Formoterol, and Glycopyrrolate Formulated with HFA-152a Using Functional Respiratory Imaging.

Angelo Matturro¹, Navid Monshi Tousi², Hosein Sadafi², Erika Cuoghi¹, Sara Panigone¹, Diego González-Segura¹, Gianluigi Poli¹, Federica Sandri¹

¹Paolo Chiesi R&D Campus, Chiesi Farmaceutici SpA, Parma, Italy.

²FLUIDDA NV, Kontich, Belgium.

PubMed DOI

Abstract

BACKGROUND: Pressurized metered-dose inhalers (pMDIs) rely on hydrofluoroalkane (HFA) propellants that have a high global warming potential (GWP). Reformulation with next-generation, low-GWP propellants, such as HFA-152a, offers a strategy to reduce climate impact; however, changes in propellant composition can affect aerosol characteristics and potentially alter lung deposition, requiring robust…

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