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Peer-Reviewed Publication
Sci Adv2026;12(29):eaeg2631.July 17, 2026Journal Article

A wearable biomechanical system for medical evaluation of soft tissue disorders.

Min-Seung Jo1, Hee-Sup Shin2, Jin-Tae Kim3, Shupeng Li4, Sonwoo Jung5,6, Jungyeon Kim3, Tae Wan Park1, Jodi L Johnson7,8,9,10, Carrie Richardson1,11, Eseosa Olive Osaghae11, Kyoung-Ho Ha1,12, Hyosik Park1,13, Josif Bozovic1,14, Winnie Sung1,14, Jaewon Lim3, Sammer Marzouk1, Yujin Choi1, Sofia Natasha Guzman15, Bridget Christina Groble15, Shuai Xu1,16, Fredrick Wigley17, Jae-Young Yoo18, Yonggang Huang5,19,20, Ann Marie Flores7,10,14,21, John A Rogers1,4,13,19,22
1Querrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
2School of Science and Engineering, University of Missouri Kansas City, Kansas City, MO, USA.
3Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
4Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.
5Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea.
6School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea.
7Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
8Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
9Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
10Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
11Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
12Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
13Department of Energy Science and Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.
14Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
15Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
16Sibel Health Inc., Chicago, IL, USA.
17Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
18Department of Semiconductor Convergence Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
19Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA.
20Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
21Cancer Survivorship Institute, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA.
22Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
PubMed DOI

Abstract

Evaluating soft tissue elasticity provides critical biomechanical insights essential for the precise characterization of various physiological and pathological conditions. Here, we present the clinical validation of a wireless, compact wearable system designed for direct, location-specific monitoring of the elastic modulus of the skin and underlying tissues via vibro-rotational biomechanical dynam…

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