Health AI Central
Peer-Reviewed Publication
Diagnostics (Basel)2026;16(13)June 24, 2026Journal Article

The Sepsis ImmunoScore Predicts Sepsis, Mortality, and Deterioration Better than Clinical Scores and Widely Available Biomarkers.

Gregory L Watson1, Lincoln C Updike1, Carlos G López-Espina1, Akhil Bhargava1, Lee A Schmalz1, Shah Khan1, Dennys S Urdiales1, Matthew D Sims2,3, Ashok V Palagiri4, Adrian D Haimovich5, Alon Dagan5, Benjamin P Davis6, Karen C White6, Paul A Gurbel7, Stockton M Mayer8, Anwaruddin Syed9, Sihai Dave Zhao10, Ruoqing Zhu10, Rashid Bashir11, Nathan I Shapiro1,5,12, Bobby Reddy1
1Prenosis, Inc., Chicago, IL 60616, USA.
2Department of Medicine, Section of Infectious Diseases and International Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, MI 48073, USA.
3Departments of Internal Medicine and Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA.
4Mercy Hospital, St. Louis, MO 63141, USA.
5Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
6Carle Foundation Hospital, Urbana, IL 61801, USA.
7Sinai Hospital of Baltimore, LifeBridge Health, Baltimore, MD 21215, USA.
8Jesse Brown VA Medical Center, Chicago, IL 60612, USA.
9OSF Saint Francis Medical Center, Peoria, IL 61637, USA.
10Department of Statistics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
11Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
12Department of Emergency Medicine, Harvard Medical School, Boston, MA 02115, USA.
PubMed PMC DOI PDF

Abstract

Background: Early and accurate risk stratification of patients suspected of serious infection is essential for improving outcomes, but existing diagnostic and predictive tools have limited accuracy. The objective was to compare the performance of an FDA-authorized AI diagnostic test, the Sepsis ImmunoScore, against widely available biomarkers and clinical tools for diagnosis of sepsis and predicti…

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