Peer-Reviewed Publication
RSC Adv2026;16(36):37636-37652.August 5, 2026Journal Article
Eudragit S100-coated microbeads of thiolated chitosan/casein for pH-responsive colon-targeted delivery of 6-mercaptopurine.
Huma Hameed1, Syed Muhammad Ahmad2, Shazia Akram Ghumman3, Ali Irfan4,5, Hafiz Shoaib Sarwar1, Yousef A Bin Jardan6
1Faculty of Pharmaceutical Sciences, University of Central Punjab (UCP) Lahore 54000 Pakistan huma.hameed@ucp.edu.pk Shoaib.sarwar@ucp.edu.pk.
2Department of Pharmaceutics, Graduate School of Biomedical Sciences, Nagasaki University 1-7-1 Sakamoto Nagasaki 852-8501 Japan bb55625081@ms.nagasaki-u.ac.jp.
3College of Pharmacy, University of Sargodha Sargodha-40100 Pakistan shazia.akram@uos.edu.pk.
4Department of Chemistry, Government College University Faisalabad Faisalabad-38000 Pakistan raialiirfan@gmail.com.
5The Green Institute of Chemical Biomedical and Environmental Sciences (GICBES) Lahore-54000 Pakistan.
6Department of Pharmaceutics, College of Pharmacy, King Saud University Riyadh 11451 Saudi Arabia ybinjardan@ksu.edu.sa.
Abstract
6-Mercaptopurine (6-MP) is a potent chemotherapeutic and immunosuppressive agent; however, its oral administration is limited by poor bioavailability and dose-dependent hepatotoxicity. This study aimed to develop and optimize a colon-targeted, pH-responsive delivery system for 6-MP using Eudragit S100-coated thiolated chitosan/casein microbeads (Eu-S100@TCh/CS) to enhance site-specific release and…
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