Peer-Reviewed Publication
Otolaryngol Head Neck Surg2026July 10, 2026Journal Article
Development of Novel mRNA Classifiers to Stratify Preoperative Thyroid Tumor Risk.
Thomas F Barrett1, Mohamed Jama1, Mohammed Alshalalfa2, Theresa Tharakan1, Yangyang Hao2, Joshua P Klopper2, Taylor B Cavazos2, Ryan S Jackson1,3, Patrik Pipkorn1,3, Jason T Rich1,3, Paul A Zolkind1,3, Douglas R Adkins3,4, Peter Oppelt3,4, Anthony J Apicelli3,5, Nikhil Rammohan3,5, Taylor C Brown6, Sidharth V Puram1,3, Sina Jasim7, R Alex Harbison1,3
1Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
2Veracyte Inc., South San Francisco, California, USA.
3Robert Ebert and Greg Stubblefield Head and Neck Tumor Center at the Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA.
4Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
5Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
6Department of Surgery, Section of Surgical Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
7Department of Medicine, Division of Endocrinology, Washington University School of Medicine, St. Louis, Missouri, USA.
Abstract
OBJECTIVE: Develop a preoperative risk classifier for guiding the extent of surgery in differentiated thyroid carcinomas (DTCs) under 4 cm.
STUDY DESIGN: In silico study, validation with retrospective cohort.
SETTING: Genomic data repositories, academic tertiary medical center.
METHODS: Prognostic transcriptional groups and American Thyroid Association (ATA) risk groups in The Cancer Genome Atl…
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