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Discov Nano2026;21(1)July 10, 2026Journal Article

Oridonin loaded amphiphilic hyaluronic acid polymeric micelle with tunable redox sensitive property for CD44 targeted lung cancer therapy.

Shaoyan Xuan1, Shenglei Yang2, Yuqin Mao1, Zhiyong Chen2,3,4, Yue Zhu2,3,4, Ying Zhou2,3, Jie Huang5, Xiuliang Zhu6, Zuhua Wang7,8,9
1Department of Pharmacy, Shaoxing People's Hospital, Zhongxing North road 568, Shaoxing, 312000, China.
2College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.
3Guizhou Key Laboratory of Modern Traditional Chinese Medicine Creation, Guiyang, 550025, China.
4Traditional Chinese Medicine Preparation and Big Health Products Development-Guizhou Provincial Science and Technology Innovation Leading Talent Workstation, Guiyang, 550025, China.
5Shaoxing Seventh People's Hospital (Affiliated Mental Health Center, Medical College of Shaoxing University), Shengli West Road 1234, Shaoxing, 312000, China. sxskqyy_hj@163.com.
6Department of radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, PR China. zhuxiul@zju.edu.cn.
7College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China. wangrui551601@163.com.
8Guizhou Key Laboratory of Modern Traditional Chinese Medicine Creation, Guiyang, 550025, China. wangrui551601@163.com.
9Traditional Chinese Medicine Preparation and Big Health Products Development-Guizhou Provincial Science and Technology Innovation Leading Talent Workstation, Guiyang, 550025, China. wangrui551601@163.com.
PubMed PMC DOI PDF

Abstract

Lung cancer remains one of the most prevalent and lethal malignancies worldwide. Oridonin (ORI) exhibits remarkable anti-lung cancer activity. Nevertheless, its clinical application in lung cancer therapy is severely hindered by poor solubility, fast metabolism, insufficient tumor penetration, and low selectivity. In this study, we developed a redox-responsive polymeric micelle (HA-cys-TOS) target…

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