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Open Heart2026;13(2)July 9, 2026Journal Article

Prevalence and burden of coronary artery disease in young adults undergoing clinically indicated coronary CT angiography.

Kevin J O'Gorman1,2, Gil Metser1, Sarah Mullen3, Nicholas Ng3, Jay Leb4, Yiyi Zhang5, Daichi Shimbo6, Campbell Rogers3, Ana Navas-Acien7, Jonathon Leipsic8, Andrew J Einstein9,4
1Seymour, Paul and Gloria Division of Cardiology, Department of Medicine, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.
2Department of Medicine, Uniformed Services University F. Edward Hébert School of Medicine, Bethesda, Maryland, USA.
3HeartFlow, Inc, San Francisco, California, USA.
4Department of Radiology, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.
5Division of General Medicine, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.
6Paul and Gloria Division of Cardiology, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.
7Department of Environmental Health Sciences, Mailman School of Public Health, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.
8Centre for Cardiovascular Innovation, St Paul's Hospital, Vancouver, Washington, Canada.
9Seymour, Paul and Gloria Division of Cardiology, Department of Medicine, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA ae2214@cumc.columbia.edu.
PubMed PMC DOI PDF

Abstract

BACKGROUND: The reported prevalence and burden of coronary artery disease in young adults varies markedly in published studies from the 1950s through 2000s but has not been evaluated in a large contemporary multicentre cohort of young adults referred for clinically indicated coronary CT angiography (CCTA). METHODS: Retrospective, international, multicentre, cross-sectional study of consecutive pa…

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