Health AI Central
Peer-Reviewed Publication
bioRxiv2026June 4, 2026Journal Article

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation.

Tolani F Olonisakin1,2, Fernando T Zamuner2, Kenny Vu1, Sreenivasulu Gunti1, Yiming Ding3, Yue Hou4, Xinping Yang5, Ramya Viswanathan1, Angel Huynh5, Federico Comoglio6, Marco Notaro6, Christopher Cherry7, Michael Patatanian7, Nathan Wong8,9, Timothy R DeKlotz10, Jean Kim2, Wayne Koch2, Andrew P Lane2, Murugappan Ramanathan2, Nicholas R Rowan2, Matt Lechner11, Aaron Udager12, Evgeny Izumchenko13, Clint T Allen5, Nyall R London1,2,14,15
1Sinonasal and Skull Base Tumor Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
2Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.
3Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.
4Akoya Biosciences Inc, Marlborough, MA, USA.
5Section on Translational Tumor Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
6enGene Statistics GmbH, Basel, Switzerland.
7C.M. Cherry Consulting, Baltimore, MD, USA.
8Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
9CCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
10Department of Otolaryngology - Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
11Division of Surgery and Interventional Science and UCL Cancer Institute, University College London, London, UK.
12Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
13Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL, USA.
14Department of Neurosurgery, Johns Hopkins Medicine, Baltimore, MD, USA.
15Department of Oncology, Johns Hopkins Medicine, Baltimore, MD, USA.
PubMed PMC DOI PDF

Abstract

Sinonasal inverted papilloma (IP) carries a 10% risk of malignant transformation to IP-associated sinonasal squamous cell carcinoma (IP-SNSCC), yet the molecular and immune drivers of this progression remain poorly defined. This study integrates single-cell RNA sequencing, multiplexed spatial proteomics, whole-exome sequencing, and functional assays across IP and IP-SNSCC cohorts to define mechani…

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