Pre-existing anxiety and mood disorders and multisystem outcomes in young adults with chronic kidney disease.

Lino Merlino^1,2,3, Francesco Rainone^1,2, James Tollit^1,2, Michael J Kalra², Sarah Williford⁴, Francesca Rusconi⁴, Graziana G Battini³, Ross A Dunne^5,6, Philip A Kalra^1,2, Constantina Chrysochou^1,2

¹Manchester University, Department of Cardiovascular Sciences, Manchester, UK.

²Donal O'Donoghue Renal Research Centre, Salford Royal Hospital, Salford, UK.

³Vimercate Hospital, Department of Nephrology, ASST Brianza, Vimercate, Italy.

⁴TriNetX Europe NV, Sint-Martens-Latem, Belgium.

⁵Greater Manchester Dementia Research Centre, Greater Manchester Mental Health Foundation Trust, Manchester, UK.

⁶Geoffrey Jefferson Brain Research Centre, University of Manchester, UK.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Anxiety and mood disorders (AMD) are common in young adults and may amplify medical risk in chronic kidney disease (CKD). However, their prognostic impact in young adults with moderate-severe CKD remains poorly defined. We investigated whether pre-existing AMD identify a subgroup of young CKD patients at increased risk of adverse clinical outcomes. METHODS: Using the TriNetX Global Co…

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