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Mol Psychiatry2026July 7, 2026Journal Article

Molecular genetic influences on sustained attention and executive processes and their links with psychopathology in the AFFECT study.

Justin D Tubbs1,2,3,4, Travis T Mallard5,6,7,8, Maria Dalby9, Yunxuan Jiang10, Younga H Lee11,12,13,14, Karmel W Choi11,12,13,14, Tian Ge11,12,13,14, Niels Plath9, Lene Hammer-Helmich9, Julie M Granka10, , Andrew D Grotzinger15,16, David Hinds10, Jordan W Smoller11,12,13,14, Joshua W Buckholtz13,17
1Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. jtubbs@mgh.harvard.edu.
2Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. jtubbs@mgh.harvard.edu.
3Department of Psychiatry, Harvard Medical School, Boston, MA, USA. jtubbs@mgh.harvard.edu.
4Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. jtubbs@mgh.harvard.edu.
5Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. tmallard@mgh.harvard.edu.
6Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. tmallard@mgh.harvard.edu.
7Department of Psychiatry, Harvard Medical School, Boston, MA, USA. tmallard@mgh.harvard.edu.
8Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. tmallard@mgh.harvard.edu.
9H. Lundbeck A/S, Valby, Denmark.
1023andMe Inc, Sunnyvale, CA, USA.
11Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
12Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
13Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
14Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
15Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
16Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
17Department of Psychology, Stanford University, Stanford, CA, USA.
PubMed DOI

Abstract

Both sustained attention (SA) and executive functioning (EF) are critical for adaptive behavior and compromised across a range of psychiatric disorders, yet their etiological relationships remain underexplored. Here, we report the first multivariate characterization of molecular genetic influences on SA (vigilance, lapse recovery cost, lapse propensity) and EF (processing speed, response selection…

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