Health AI Central
Peer-Reviewed Publication
JAMA Netw Open2026;9(7):e2622463.July 1, 2026Journal Article

Patient Perspectives on AI-Drafted Electronic Portal Messages.

Kellie Owens1, Athmeya Jayaram1, Anand Chowdhury2, Kathryn I Pollak3, Sam Klotman4, Zachary Griffen5, Miles Danielski6, Ben Goldstein7, Jennifer Maddocks4, Matthew Roman4, Eric G Poon4, Armando Bedoya2, Joanna Cavalier2
1The Hastings Center for Bioethics.
2Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
3Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina.
4Department of Health Technology Solutions, Duke University Health System, Durham, North Carolina.
5Department of Population Health, New York University Grossman School of Medicine, New York.
6Wesleyan University, Middletown, Connecticut.
7Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina.
PubMed PMC DOI PDF

Abstract

IMPORTANCE: Patient portal messaging volume has increased substantially and is linked to clinician burnout. In response, health systems are increasingly adopting large language models (LLMs) to generate draft replies to patient messages, yet little is known about how patients interpret and evaluate artificial intelligence (AI) involvement in this communication channel. OBJECTIVE: To understand ho…

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