Peer-Reviewed Publication
Rheum Dis Clin North Am2026;52(3):439-465.August 1, 2026Journal Article

Essential Informatics Tools and Computing Infrastructure for Big Data to Advance Artificial Intelligence in Rheumatology.

Jeffrey R Curtis1, Emily Holladay2, Tapan Mehta3, John Osborne4
1Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: jrcurtis@uabmc.edu.
2Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
3Department of Family and Community Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
4Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Abstract

Rheumatic diseases are chronic, heterogeneous, and longitudinal, and assembling real-world evidence for effectiveness and safety for their study is best served by integrating diverse data types. This article describes the infrastructure required to support scalable, trustworthy artificial intelligence (AI) in rheumatology, emphasizing data acquisition, harmonization, linkage, privacy protection, a…

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