Neuromelanin-sensitive MRI for identifying dopamine transporter imaging abnormality risk in idiopathic rapid eye movement sleep behavior disorder.

Jae Rim Kim¹, Beomseok Sohn², Jeong Won Jo³, Hwan Heo³, Soohwa Song³, Eung Yeop Kim⁴, Eun Yeon Joo⁵

¹Department of Neurology, Chungnam National University Sejong Hospital, Chungnam National University School of Medicine, Sejong, Republic of Korea.

²Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

³Heuron Co., Ltd, Incheon, Korea.

⁴Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. neuroradkim@gmail.com.

⁵Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. ejoo@skku.edu.

PubMed PMC DOI PDF

Abstract

Neuromelanin-sensitive magnetic resonance imaging (NM-MRI) enables non-invasive assessment of the substantia nigra pars compacta (SNpc). However, its utility in identifying dopaminergic dysfunction in idiopathic rapid eye movement sleep behavior disorder (iRBD) remains unclear. This study evaluated NM-MRI alterations in the SNpc, stratified by dopamine transporter (DaT) imaging status, to assess i…

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