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Immune Netw2026;26(3):e21.June 1, 2026Journal Article

Synergistic Induction of Neutrophilic Inflammatory Programs by Staphylococcus aureus and Cigarette Smoke in Airway Epithelial Cells.

Ha-Kyeong Won1, Jiwon Lee2, Jae Won Yun3, Kyung Eun Park4, Ji-Hyang Lee5, You Sook Cho6, Sang Heon Cho7, Kian Fan Chung8, Claus Bachert9,10, Jun-Pyo Choi11, Woo-Jung Song6
1Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju 28644, Korea.
2Institute of Allergy and Clinical Immunology, Asan Medical Research Center, Seoul 05505, Korea.
3Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Korea.
4University of Ulsan College of Medicine, Ulsan 44601, Korea.
5Lunit, Seoul 06241, Korea.
6Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
7Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
8National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
9Department of Otorhinolaryngology, Head and Neck Surgery and the German Center of Diseases of the Upper Airway, University Hospital Münster, Münster 48149, Germany.
10Department of Otorhinolaryngology, First Affiliated Hospital of Sun Yat-sen University, International Airway Research Center, Guangzhou 510080, China.
11Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
PubMed PMC DOI PDF

Abstract

Staphylococcus aureus (SA) colonization and cigarette smoking are both implicated in the pathogenesis of chronic airway disease, yet their combined effects on epithelial responses remain unclear. We investigated transcriptomic changes in human bronchial epithelial cells (BEAS-2B) following co-exposure to SA and cigarette smoke extract (CSE). RNA sequencing revealed that combined SA+CSE co-exposure…

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