Comparison of intra-articular injectable polydactyly-derived chondrocyte sheet-minis with direct transplantation of intact polydactyly-derived chondrocyte sheets in a rat full-thickness cartilage defect model.

Makoto Ogawa^1,2, Eriko Toyoda^1,2,3, Shiho Wasai^1,2, Tatsumi Tanaka^1,2, Ryoka Uchiyama^1,2, Miki Maehara^1,2, Tadashi Akamatsu⁴, Masahiko Watanabe^1,2, Masato Sato^1,2,3

¹Department of Orthopedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

²Center for Musculoskeletal Innovative Research and Advancement(C-MiRA), Tokai University Graduate School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

³The Institute of Medical Sciences, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

⁴Department of Plastic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

PubMed PMC DOI PDF

Abstract

INTRODUCTION: Polydactyly-derived chondrocyte (PD) sheets are being developed as an allogeneic cell sheet therapy for cartilage defects associated with knee osteoarthritis. Although intact PD sheets can promote hyaline cartilage repair, transplantation requires invasive open procedures. Injectable fragments of PD sheets (PD sheet-minis) may reduce invasiveness. However, their in vivo repair capaci…

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