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Peer-Reviewed Publication
Am J Prev Cardiol2026;29101624.October 1, 2026Journal Article

Association of rheumatoid arthritis with major adverse cardiovascular events despite normal myocardial perfusion imaging.

Bailey A Frohlich1, Jacqueline M Pires2, Ioannis Kyrakoulis3, Catherine X Wright2, Ibolya Csecs2, Ahmed I Ahmed1, Xaviar Jones1, Menachem M Jacobs1, Monique Hinchcliff4, Edward J Miller2,5, Attila Feher2,5
1Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06410, United States.
2Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06410, United States.
3Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
4Section of Rheumatology, Allergy & Immunology, Department of Internal Medicine Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06410, United States.
5Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06410, United States.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Rheumatoid arthritis (RA) is recognized as a cardiovascular risk-enhancing condition. Whether a normal myocardial perfusion imaging (MPI) study confers similar prognostic reassurance in RA as in non-RA patients remains unclear. METHODS: We retrospectively analyzed 282 patients with RA and 282 matched controls without autoimmune disease who underwent SPECT or PET MPI. Matching included…

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