Lateralized cerebral arterial blood flow and blood pressure adaptations to short-term head-down tilt: a 4D flow MRI study with cognitive function assessment.

Huan-Ran Hou¹, Ting-Ting Zhang¹, Ya-Wen Liu¹, Lin-Kun Cai¹, Yan Huang¹, Rui Wang¹, Hong-Yuan Wang², Jumatay Biekan³, Peng-Gang Qiao¹, Zheng-Han Yang¹, Zhen-Chang Wang¹, Peng-Ling Ren¹, Peng-Fei Zhao¹

¹Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

²Department of Statistics, Iowa State University, Ames, IA 50011, USA.

³Circle Cardiovascular Imaging, Calgary, AB T2P 1H5, Canada.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Simulated microgravity, modeled by head-down tilt (HDT), induces cephalad fluid shifts that perturb intracranial hemodynamics and may affect cognitive function. However, the temporal adaptation of cerebral arterial blood flow (CaBF), both during simulated microgravity and throughout the recovery phase, remains incompletely understood. METHODS: In this study, 38 healthy male participan…

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