Health AI Central
Share:
Peer-Reviewed Publication
J Mol Biol2026;169917.June 29, 2026Journal Article

Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry.

Daniele Peterle1, Nicholas L Yan2, Elena S Klimtchuk3, Bindu Y Srinivasu4, Vesna Brusic3, Thomas E Wales4, Olga Gursky5, Jeffery W Kelly2, John R Engen4, Gareth J Morgan6
1Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA. Electronic address: daniele@peptone.io.
2Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
3Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
4Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA.
5Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
6Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Section of Hematology and Medical Oncology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: gjmorgan@bu.edu.
PubMed DOI

Abstract

Immunoglobulin light chains, a component of antibodies, can misfold and aggregate to cause systemic AL amyloidosis. Aggregation, including amyloid fibril formation, requires unfolding of the full-length light chain from its native state, and in most cases aberrant proteolysis. Small molecules that bind to the native state of light chains to stabilize them against conformational excursions and prot…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free AccountSign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.