Non-Parametric Ancestry Adjustment for Polygenic Scores.

Daniel Mas Montserrat¹, Míriam Barrabés¹, Carlos D Bustamante¹, Alexander G Ioannidis²

¹Galatea Bio, Miami, FL.

²Stanford University, Stanford, CA.

Abstract

Modern polygenic risk scores (PRS) exhibit shifts correlated with ancestry, leading to erroneous predictions for non-European individuals when models are trained on predominantly European cohorts. Such shifts arise from, among other factors, (1) algorithmic limitations in the ability of PRS model training to detect causal variants, rather than nearby variants with ancestry-dependent correlations t…

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